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ea0029p1176 | Obesity | ICEECE2012

Brown rice and its component, γ-oryzanol, attenuate the preference for dietary fat by decreasing hypothalamic endoplasmic reticulum stress in mice

Kozuka C. , Yabiku K. , Sunagawa S. , Ueda R. , Taira S. , Ikema T. , Yamakawa K. , Higa M. , Shimabukuro M. , Masuzaki H.

It is known that brown rice (BR) prevents obesity and type 2 diabetes in humans. Previous studies have shown that exaggerated endoplasmic reticulum (ER) stress in the hypothalamus of obese mice is linked to hyperphagia. Here we tested the hypothesis that BR might decrease ER stress in hypothalamus, leading to the attenuation the preference for dietary fat.Eight-week-old mice were randomly divided into three groups: the control, BR-containing diet, and th...

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ea0005s23 | The Adipocyte as an Endocrine Organ | BES2003

Reduced intra-adipose glucocorticoid regeneration: A novel adaptive response to, and therapy for, the metabolic syndrome

Morton N , Paterson J , Masuzaki H , Holmes M , Staels B , Fievet C , Walker B , Flier J , Mullins J , Seckl J

Metabolic Syndrome (visceral obesity, insulin resistance, type2 diabetes) resembles Cushing's syndrome, but lacks elevated circulating cortisol levels. This has engendered the hypothesis that excessive local glucocorticoid regeneration, resulting from elevated adipose 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD-1) underlies the Metabolic Syndrome. We report that 11beta-HSD-1 nullizygosity (11beta-HSD-1-/-) reduced intra-adipose corticosterone levels and i...

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Endocrine Abstracts

Brown rice and its component, γ-oryzanol, attenuate the preference for dietary fat by decreasing hypothalamic endoplasmic reticulum stress in mice

Reduced intra-adipose glucocorticoid regeneration: A novel adaptive response to, and therapy for, the metabolic syndrome

BiosciAbstracts